TABLE 1.

Summary of key studies of venous thromboembolism (VTE) risk in cirrhosis

Author (reference), year	Study design	Patients, n/controls, n	Main results
Heit et al (21), 2000	Case control	625/625	Reduced risk of VTE (OR 0.10) in chronic liver disease
Ali et al (22), 2011	Case control	8248/441,551	VTE incidence 1.8% in cirrhotic patients compared with 3.7% in overall hospitalized patients
Aldawood et al (23), 2011	Retrospective cohort	226	VTE incidence 2.7% in hospitalized cirrhotic patients
Huerta et al (24), 2007	Case control	6550/10,000	Increased risk of VTE (OR 1.65) in chronic liver disease
Gulley et al (25), 2008	Case control	963/12,405	VTE incidence increased in cirrhosis 1.8% versus 0.9% in controls (P=0.007).
			Low albumin was predictive of VTE
Sogaard et al (26), 2009	Case control	67,519/308,614	Relative risk for VTE is 2.06 for liver cirrhosis and 2.10 for noncirrhotic liver disease
Wu and Nguyen (27), 2010	Case control	640,000 /575,000	Increased risk VTE in cirrhosis: OR 1.23 in compensated cirrhotic patients; OR 1.39 in decompensated cirrhotic patients
Northup et al (28), 2006	Case control	113/113	0.5% of hospitalized cirrhotics had first VTE. Low albumin was predictive of VTE
Dabbagh et al (30), 2010	Retrospective cohort	190	VTE incidence in hospitalized patients with chronic liver disease was 6.3%. Prolonged international normalized ratio was not protective from hospital-acquired VTE

CLD Chronic liver disease