TABLE 9.
Relative activity of hepatitis B antivirals in the presence of pre-existing mutations in the polymerase gene
|
Resistance mutation
|
||||
|---|---|---|---|---|
| Lamivudine resistant | Adefovir resistant | Adefovir resistant | Entecavir resistant | |
|
|
||||
| L180M + | N236T | A181V | L180M + | |
| M204V, M204I | M204V/I + | |||
| I169T +/− | ||||
| T184G +/− | ||||
| S202I +/− | ||||
| M250V | ||||
|
| ||||
| Mutation confers reduced sensitivity to listed drugs | Lamivudine, entecavir, telbivudine | Adefovir, tenofovir | Adefovir, lamivudine | Entecavir, lamivudine, telbivudine |
| Drugs remaining active | Adefovir, tenofovir | Lamivudine, entecavir, telbivudine | Tenofovir, entecavir | Adefovir, tenofovir |
−
Negative;
+
Positive