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. Author manuscript; available in PMC: 2013 Jan 22.
Published in final edited form as: Gastroenterology. 2011 Mar 25;141(1):259–268.e8. doi: 10.1053/j.gastro.2011.03.043

Figure 6.

Figure 6

Inhibition of Dkk1 phenocopies genetic Dkk1 reduction in vivo. Wild-type mice treated for 1 week with a functional Dkk1 antibody showed an increased number of Ki67-positive crypt cells (A) and increased crypt length (B) in the proximal colon. (C) DSS-induced colitis led to a significant crypt lengthening in mice receiving Dkk1 antibody for 1 week. (D) Immunohistochemistry revealed decreased β-catenin phosphorylation at S552 in anti-Dkk1 treated mice during acute colitis. Scale bars = 100 μm. (E) Clinical disease activity index and (F) relative body weight of mice that received DSS for 7 days, followed by 7 days of regular drinking water. Animals were treated daily with the indicated antibody. n = 5 per group. Quantitative data in A and B are derived from 2 to 3 mice per group and data in C from 6 mice per group. *P < .001, **P < .05.