Table 1.

Effects of XH-14 on LPS-induced mRNA expression of iNOS, COX-2, IL-1β and IL-6 in RAW 264.7 cells¹

mRNA	iNOS	COX-2	IL-1β	IL-6
(relative expression)
vehicle	NDa	ND	ND	ND
LPS	1.00 ± 0.00	1.00 ± 0.00	1.00 ± 0.00	1.00 ± 0.00
LPS + 1 μM XH-14	1.14 ± 0.21	0.80 ± 0.23	0.90 ± 0.02	0.74 ± 0.27
LPS + 5 μM XH-14	0.79 ± 0.12**	0.69 ± 0.25	0.45 ± 0.06***	0.75 ± 0.11**
LPS + 20 μM XH-14	0.65 ± 0.03***	0.71 ± 0.01***	0.37 ± 0.03***	0.59 ± 0.05***

¹LPS-stimulated RAW 264.7 cells were cultured with 0–20 μM XH-14 in the presence or absence for 6 h and gene expression was quantified by real-time RT-PCR. The results are reported as mean ± SEM of three independent experiments in triplicate. Statistical significance is based on the difference when compared with LPS-stimulated cells (^**P < 0.01, ^***P < 0.001).

^a ND; Not detected.