Table 3.
Summary of cytogenetic effect of LI10903F in mammalian cells
| Test | Test Parameters | Negative control | LI10903F 2000mg/kg | Cyclophosphamide 40 mg/kg |
|---|---|---|---|---|
|
Mammalian Erythrocyte Micronucleus Test |
No. of immature Erythrocytes scored |
2000 |
2000 |
2000 |
| No. of Micronuclei present in immature erythrocytes |
0.60±0.54 |
0.80±0.49 |
45.80±4.44 |
|
|
Test |
Test Parameters |
Negative control |
LI10903F 5000μg/ml |
Mitomycin C 0.2 μg/ml |
|
Mammalian Chromosome Aberration Test |
No. of lymphocytes scored |
100 |
100 |
100 |
| |
% Numerical Aberrations |
0 |
1.50±0.71 |
30.50*±7.78 |
| |
No. of cells with one structural aberration |
0 |
1.50±0.71 |
39.00*±5.66 |
| |
No. of cells with two structural aberrations |
0.50±0.71 |
0.50±0.71 |
38.00*±4.24 |
| % Mitotic Index | 3.65±0.12 | 2.65±0.21 | 1.30*±0.14 |
ANOVA, * Significant (p<0.05).