Table 1.
Changes in gene expression of neuropeptides, cytokines and in optical density of tenocyte viability after triamcinolone acetonide treatment at seven time points (0, 1, 3, 5, 24, 48, 72 hours)
|
No TAA |
After TAA treatment |
Statistical significance (p)* | ||||||
|---|---|---|---|---|---|---|---|---|
| 0 hr | 1 hrs | 3 hrs | 5 hrs | 24 hrs | 48 hrs | 72 hrs | ||
|
SP |
1.000 |
0.527± 0.154 |
0.881 ±0.326 |
0.652 ±0.246 |
0.412±0.166 |
0.527 ±0.189 |
0.696 ±0.235 |
0.0078 |
|
CGRP |
1.000 |
1.119± 0.336 |
1.197 ±0.308 |
0.958 ±0.312 |
0.359 ±0.153 |
0.268 ±0.161 |
0.330 ±0.164 |
< 0.0001 |
|
IL-1α |
1.000 |
1.183 ±0.35 |
0.342 ±0.168 |
0.185± 0.091 |
0.210 ±0.166 |
0.107± 0.114 |
0.053 ±0.027 |
< 0.0001 |
|
TGF-β |
1.000 |
1.108 ±0.225 |
1.132 ±0.219 |
1.186±0.249 |
1.015±0.198 |
0.859 ±0.234 |
0.772 ±0.228 |
0.0187 |
| Tenocyte viability | 0.582 | 0.491± 0.038 | 0.502 ±0.041 | 0.467 ±0.049 | 0.405 ±0.042 | 0.353 ±0.033 | 0.306 ±0.021 | < 0.0001 |
The values are given either as mean ± SD.
SP = Substance P.
CGRP = Calcitonin gene related peptide.
IL-1α = Interleukin-1α.
TGF-β = Tumor growth factor-β.
TAA = Triamcinolone acetonide.
*Repeated measures ANOVA.