Table 3.

Samples in the unseen population dataset with discordant call between the genotypic algorithms

	Genotypic algorithms						Linear models
	ANRS (May 2011)		Rega v8.0.2		Stanford 6.0.11		First order		Second order
Samplea	mutations	call	mutations	call	mutations	call	mutations	BCO call	mutations	BCO call
L74ILM	72I, 74M	S	74M, 156N	I	74M	S	74M	S	74M	S
L74M, A91 T, T97A/T, F121Y	72I, 74M, 97A, 121Y	R	74M, 97A, 206S	I	74M, 97A, 121Y	I	74M, 91T, 97A, 119R, 121Y	R	74M, 91 T, 97A, 119R, 121Y	R
L74M, K103R, I135V, I200L	72I, 74M	S	74M	I	74M	S	74M, 135V, 200L	R	74M, 103R	R
L74M, V151A/V	72I, 74M	S	74M	I	74M, 151A	S	74M, 135V, 200L	R	74M, 103R	S
A91 T, F121Y	72I, 121Y	R	206S	S	121Y	I	91 T, 119R, 121Y	R	91T, 119R, 121Y	R
T97A	72I, 97A	S	97A, 206S	I	97A	S	25E, 97A	R	25E, 97A	S
E138E/K	72I	S	138K, 206S	S	138K	I	135V	S	-	S
E138E/K	-	S	138K	S	138K	I	25E	S	25E	S
E157Q	72I, 157Q	R	156N	S	157Q	S	-	S	-	S
E157Q	72I, 157Q	R	206S	S	157Q	S	135V	S	-	S
E157Q	157Q	R	-	S	157Q	S	-	S	-	S
E157Q	157Q	R	156 N, 206S	S	157Q	S	-	S	-	S

^aHXB2 reference amino acid is shown.

The mutations on which the RAL S(usceptible)/I(ntermediate)/R(esistant) call is based, are listed. For the linear models, the call is R(esistant) if FC prediction is above the RAL biological cutoff (BCO = 2.0).