Table 2.
Preoperative radiotherapy (RT) (followed by planned surgical admission) in 5,437 incident rectal cancer patients
| |
Total (N=5437) |
Preoperative RT (N=727) |
Random-effect model* |
||
|---|---|---|---|---|---|
| No. | % | OR | 95% CI | P | |
|
Age (years) |
|
|
|
|
|
| ≤60 |
1,082 |
19.2 |
1 |
|
<0.001 |
| 61-70 |
1,707 |
14.8 |
0.71 |
(0.57-0.90) |
|
| 71-80 |
1,958 |
11.4 |
0.51 |
(0.40-0.65) |
|
| >80 |
690 |
6.1 |
0.24 |
(0.16-0.35) |
|
|
Gender |
|
|
|
|
|
| Male |
3,375 |
14.2 |
1 |
|
0.03 |
| Female |
2,062 |
12.1 |
0.77 |
(0.64-0.93) |
|
|
Educational level |
|
|
|
|
|
| Secondary or more |
813 |
13.9 |
1 |
|
<0.001 |
| Intermediate |
1,244 |
15.3 |
1.35 |
(1.03-1.77) |
|
| Primary |
2,869 |
11.7 |
1.41 |
(1.09-1.83) |
|
| Unknown |
511 |
17.4 |
1.16 |
(0.79-1.71) |
|
|
Marital status† |
|
|
|
|
|
| Married |
3,720 |
13.3 |
1 |
|
<0.001 |
| Unmarried |
1,352 |
11.5 |
0.99 |
(0.80-1.23) |
|
| Unknown |
365 |
20.8 |
0.84 |
(0.58-1.20) |
|
|
Disease staging |
|
|
|
|
|
| Absence of metastases |
4,836 |
13.9 |
1 |
|
0.01 |
| Presence of metastases |
601 |
8.8 |
0.47 |
(0.35-0.65) |
|
|
Comorbidity (Charlson index) |
|
|
|
|
|
| 0 |
4,068 |
14.1 |
1 |
|
0.01 |
| ≥1 |
1,369 |
11.2 |
0.73 |
(0.59-0.90) |
|
|
Year of admission |
|
|
|
|
|
| 2000 |
654 |
6.9 |
1 |
|
<0.001 |
| 2001 |
706 |
9.6 |
1.51 |
(1.00-2.29) |
|
| 2002 |
617 |
12.3 |
1.96 |
(1.30-2.95) |
|
| 2003 |
607 |
15.3 |
2.76 |
(1.85-4.11) |
|
| 2004 |
729 |
16.0 |
2.98 |
(2.02-4.40) |
|
| 2005 |
691 |
16.5 |
2.90 |
(1.96-4.29) |
|
| 2006 |
738 |
15.2 |
2.82 |
(1.90-4.17) |
|
| 2007 |
695 |
14.7 |
3.04 |
(2.03-4.56) |
|
|
RT service |
|
|
|
|
|
| Absent |
2,775 |
9.4 |
1 |
|
<0.001 |
| Present |
2,662 |
17.5 |
2.24 |
(1.77-2.85) |
|
|
Distance to RT service (min.) |
|
|
|
|
|
| Same city or <15’ |
2,576 |
15.6 |
1 |
|
<0.001 |
| 15’ to <30’ |
1,984 |
12.2 |
0.97 |
(0.80-1.18) |
|
| ≥30’ |
877 |
9.6 |
0.82 |
(0.60-1.12) |
|
|
Hospital volume (annual caseload) |
|
|
|
|
|
| >25 |
3,076 |
17.6 |
- |
* |
<0.001 |
| 11-25 |
1,778 |
6.8 |
- |
* |
|
| ≤10 | 583 | 11.1 | - | * | |
*Given the correlation between hospital volume and presence of RT service, these predictors were not included in the models simultaneously.
†Unmarried includes single, separated, divorced and widowed.
OR: odds ratio, CI: confidence interval, APR-DRG: all-patient-refined-diagnosis-related group, RT: radiotherapy.