Table 6.

Genes from downregulated network

Gene	Full name	Role in cancer quoted from literature
CELSR2	cadherin, EGF LAG seven-pass G-type receptor 2	“Celsr2 was down-regulated in one cell line and in 7% of breast cancers” [38].
PRKCB	protein kinase C, beta	PRKCB has been observed to be downregulated in estrogen receptor negative breast cancer [39].
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog. Also known as C-Kit; CD117	Loss of c-kit expression has been reported in 80-90% of breast cancer specimens, suggesting a possible role in the development of tumors [40].
MAP2	microtubule-associated protein 2	“Elevation of MAP2 in breast cancer cell lines led to increased paclitaxel sensitivity” [41].
TDGF1	teratocarcinoma-derived growth factor 1. Also known as CR; CRGF; CRIPTO	“Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis” [42].
ELF1	E74-like factor 1	“All of the mouse and most human mammary tumors also displayed decreased expression of genes known to inhibit cell proliferation, including NFKBIA (IKBalpha), GADD45B, and CDKN1A (p21); transcription-related genes such as CEBP, JUN, JUNB, and ELF1;….” [43].
RUNX1	runt-related transcription factor 1	“Furthermore, we found that RUNX1 expression was reduced in high-grade primary breast tumors compared to low/mid-grade tumors” [44].
TYMS	thymidylate synthetase	“Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: a case–control study” [45].

A number of genes identified with the downregulated networks are associated with breast cancer.