Figure 4. Quantitative analysis of productive replication of Ad5 and Ad5T122 in human liver and in liver metastatic colorectal cancer tissue.
(A) Titration of infectious virus in the supernatants of liver tissue cultures collected 1 h (0d), 1d, 3d, or 5d after infection with 107 PFU of Ad5 or Ad5T122. (B) Infectious titre in supernatants of the tumour tissue infected with 107 PFU of Ad5 or Ad5T122 were quantitated 5 d after the infection. The virus titres are indicated as the tissue culture infective dose 50 (TCID50) on the y-axis. The data are presented as the mean of triplicates ± standard error.