Table 3.
Cox regression analysis of GBM patients in relation to clinicopathological factors and miRNA expression
| Variables | Subset | P-Value | Hazard ratio |
95% C.I. |
||
|---|---|---|---|---|---|---|
| Lower | Upper | |||||
|
Univariate analysis | ||||||
| Age(year) |
20-34/35-64/65+ |
1.79E-13 |
2.052 |
1.695 |
2.485 |
|
| Gender |
Male/Female |
0.801753 |
0.973 |
0.787 |
1.204 |
|
| Recurrence |
Yes/No |
8.33E-08 |
0.530 |
0.420 |
0.668 |
|
| MicroRNAs |
Percentile |
|
||||
| Decreased (low/high) |
miR-323 |
75% |
0.00430 |
1.411 |
1.114 |
1.786 |
| miR-326 |
75% |
0.03847 |
0.770 |
0.602 |
0.986 |
|
| miR-329 |
75% |
0.01816 |
1.331 |
1.050 |
1.688 |
|
| Increased (high/low) |
miR-130a |
25% |
0.01028 |
1.381 |
1.079 |
1.766 |
| miR-155 |
50% |
0.01909 |
0.778 |
0.631 |
0.960 |
|
| 75% |
0.01693 |
0.744 |
0.584 |
0.948 |
||
| miR-210 |
25% |
0.00676 |
0.723 |
0.571 |
0.914 |
|
| 50% |
0.00767 |
0.753 |
0.611 |
0.928 |
||
| Interactions |
M323*M130a@ |
75%*25% |
7E-05 |
1.243 |
1.1165 |
1.383 |
| M326*M155 |
75%*50% |
0.00432 |
0.861 |
0.778 |
0.954 |
|
| M326*M210 |
75%*25% |
0.00146 |
0.829 |
0.739 |
0.931 |
|
| M329*M130 |
75%*25% |
0.00099 |
1.196 |
1.075 |
1.331 |
|
|
Multivariate analysis | ||||||
| Age (year) |
20-34/35-64/65+ |
1.27E-08 |
1.797 |
1.469 |
2.200 |
|
| Recurrence |
Yes/No |
9.26E-05 |
0.620 |
0.488 |
0.788 |
|
| miR-323 |
75% |
0.05391 |
1.267 |
0.996 |
1.611 |
|
| miR-326 |
75% |
0.00567 |
0.701 |
0.544 |
0.901 |
|
| miR-329 |
75% |
0.07446 |
1.244 |
0.979 |
1.581 |
|
| miR-130a |
25% |
0.00994 |
1.387 |
1.082 |
1.779 |
|
| miR-155 |
50% |
0.03335 |
0.796 |
0.646 |
0.982 |
|
| miR-210 |
25% |
0.01697 |
0.749 |
0.591 |
0.949 |
|
| M323*M130a |
75%*25% |
0.00142 |
1.195 |
1.071 |
1.333 |
|
| M326*M155 |
75%*50% |
0.00097 |
0.840 |
0.758 |
0.932 |
|
| M326*M210 |
75%*25% |
0.00026 |
0.806 |
0.718 |
0.905 |
|
| M329*M130 | 75%*25% | 0.00342 | 1.177 | 1.055 | 1.313 | |
@M denotes miR.