Table 4.
Univariate and multivariate analyses of stage I/II disease-free survival and stage III/IV overall survival
| |
Univariate Analysis |
Multivariate Analysis |
Univariate Analysis |
Multivariate Analysis |
||||
|---|---|---|---|---|---|---|---|---|
| Clinical Factors | Recurrences/No. of Patients (stage I/II) | Log-Rank P | Risk Ratio (95%CI) | Wald P | Deaths/No. of Patients (stage III/IV) | Log-Rank P | Risk Ratio (95%CI) | Wald P |
| Sex |
|
0.314 |
1.0 |
NS |
|
0.337 |
1.0 |
NS |
| Female |
9/37 |
|
|
|
42/71 |
|
|
|
| Male |
9/54 |
|
|
|
43/64 |
|
|
|
| Age, years |
0.999 |
1.0 |
NS |
|
<0.001 |
3.753 |
<0.001 |
|
| <70 |
13/65 |
|
|
|
58/99 |
|
(1.746-8.070) |
|
| ≥70 |
5/26 |
|
|
|
27/36 |
|
|
|
| TNM stage |
0.222 |
1.0 |
NS |
|
0.084 |
1.0 |
NS |
|
| p I |
0/8 |
|
|
|
|
|
|
|
| p II |
18/83 |
|
|
|
|
|
|
|
| p III |
|
|
|
|
82/127 |
|
|
|
| p IV |
|
|
|
|
3/8 |
|
|
|
| Tumor invasion |
0.408 |
1.0 |
NS |
|
0.842 |
1.0 |
NS |
|
| pT1 |
0/1 |
|
|
|
|
|
|
|
| pT2 |
0/7 |
|
|
|
3/4 |
|
|
|
| pT3 |
18/77 |
|
|
|
79/125 |
|
|
|
| pT4 |
0/6 |
|
|
|
3/6 |
|
|
|
| Lymph node NO. /metastasis |
0.006 |
1.0 |
NS |
|
<.001 |
4.450 |
<.001 |
|
| 0-7/pN0 |
9/25 |
|
|
|
2/8 |
|
(2.675-7.401) |
|
| 8–12/pN1 |
4/48 |
|
|
|
65/105 |
|
|
|
| >12/pN2 |
5/18 |
|
|
|
18/22 |
|
|
|
| Grade |
|
0.329 |
1.0 |
NS |
|
0.132 |
1.0 |
NS |
| Well |
6/28 |
|
|
|
18/29 |
|
|
|
| Moderate |
8/50 |
|
|
|
55/90 |
|
|
|
| Poor |
4/13 |
|
|
|
12/16 |
|
|
|
| Tumor size, cm |
0.049 |
1.0 |
0.099 |
|
0.249 |
1.0 |
NS |
|
| <2 |
2/20 |
|
|
|
25/37 |
|
|
|
| 2-5 |
12/63 |
|
|
|
42/72 |
|
|
|
| >5 |
4/8 |
|
|
|
18/26 |
|
|
|
| Location |
0.164 |
1.0 |
NS |
|
|
0.440 |
1.0 |
NS |
| Colon |
11/40 |
|
|
|
44/75 |
|
|
|
| Rectum |
7/51 |
|
|
|
41/60 |
|
|
|
| CXCL14 |
|
0.018 |
2.92 (1.15-7.40) |
0.024 |
|
0.003 |
3.087 (1.866-5.107) |
<0.001 |
| Low |
10/69 |
|
|
|
39/68 |
|
|
|
| High | 8/22 | 46/67 | ||||||
Abbreviation: NS, not significant.