Figure 5. Coupling of editing events for ADAR2 and Grik2 transcripts. (A) Pearson correlation coefficients for coupling between the predominant self-editing sites on the ADAR2 amplicon in cortex. See legend for color codes. Black asterisks denote significance compared with bonferroni corrected critical p values. (B) Group analysis of all cortex E115 ADAR2 self-editing sites. (C) Schematic drawing (not to scale) of the editing sites detected in ADAR2 (red asterisks). The entire depicted region is intronic in the unedited pre-mRNA but editing of the -1 site causes inclusion of the open boxed section in the downstream exon. (D) Pearson correlation coefficients for coupling between all editing sites on the Grik2 amplicon in cortex. See legend for color codes. Black asterisks denote significance compared with bonferroni corrected critical p values. (E) Group analysis of all cortex E115 Grik2 editing sites. (F) Schematic drawing (not to scale) of the editing sites in Grik2 showing the five editing sites (red asterisks) detected in this study. I/V and Y/C sites are separated from G/G, M/V and Q/R sites by a 32 kb intron. Note that only one tissue, whole forebrain, was dissected from E23.