Table 2. Correlation of ADAR transcript levels with editing percentages.
| Transcript | Site | iADAR1 | cADAR1 | ADAR2 | ADAR2alt | Reported |
|---|---|---|---|---|---|---|
| Grik2 |
I/V |
|
-0.44 |
0.74 |
0.83 |
ADAR215 |
| |
Y/C |
|
|
0.78 |
0.59 |
ADAR215 |
| |
G/G |
-0.63 |
|
|
|
|
| |
M/V |
|
|
0.64 |
0.75 |
|
| |
Q/R |
|
|
0.59 |
|
ADAR215 |
| Gria2 |
Q/R |
|
|
0.43 |
|
ADAR215 |
| |
+4 |
|
|
|
|
|
| |
Hotspot (+60) |
|
|
0.66 |
0.57 |
|
| Gria3 |
R/G |
|
|
|
|
|
| Kcna1 |
I/V |
|
-0.48 |
|
0.48 |
ADAR235 |
| Htr2c |
A |
|
-0.42 |
|
|
ADAR1 and -2 44 |
| |
B |
|
-0.46 |
|
|
ADAR1 and -2 15 |
| |
C' |
|
|
0.45 |
|
|
| |
C |
|
|
|
|
ADAR1 and -2 44 |
| |
D |
|
-0.46 |
|
|
ADAR215,44 |
| Adar2 |
-16 |
-0.43 |
-0.44 |
0.54 |
0.71 |
|
| |
-8 |
|
-0.44 |
0.61 |
0.85 |
|
| |
-4 |
-0.54 |
|
0.59 |
0.69 |
|
| |
-2 |
|
-0.50 |
0.49 |
0.66 |
|
| |
-1 |
|
-0.57 |
0.67 |
0.79 |
ADAR215 |
| |
+10 |
-0.41 |
-0.47 |
0.67 |
0.78 |
|
| |
+23 |
|
|
0.60 |
0.74 |
ADAR215 |
| |
+24 |
-0.60 |
|
0.51 |
0.68 |
ADAR215 |
| |
+28 |
|
-0.63 |
|
0.50 |
|
| Flna |
Q/R |
|
|
0.50 |
0.44 |
ADAR1 and -2 4 |
| |
K/R |
|
|
|
|
|
| Blcap |
5a |
|
|
0.41 |
|
|
| |
M/V |
|
0.51 |
|
|
|
| |
Y/C |
|
|
|
|
ADAR1 and -2 21 |
| |
Q/R |
|
0.47 |
|
|
ADAR1 and -2 21 |
| |
K/R |
-0.41 |
0.53 |
|
|
ADAR1 and -2 21 |
| Igfbp7 |
B (K/R) |
-0.46 |
|
0.62 |
0.52 |
|
| C (K/R) | -0.47 | 0.74 | 0.79 |
Pearson correlation coefficients between ADAR transcript levels (qPCR data) and A-to-I editing percentages (454 data) for correlations attaining a significant p value (< 0.05, values given in bold have p values < 0.005) are indicted. Only sites averaging > 9% editing in all tissues were used for this analysis. Values of 0.1–0.3 can be considered a small positive correlation, 0.3–0.5 as a medium correlation and 0.5–1.0 as a strong correlation. See text for description of ADAR variants.