Table 4. Comparison of RVNA response to PCECV and PVRV administered by one week ID regimen (4–4-4) vs. WHO – prequalified vaccines administered by Updated TRC/TRC, 4-site (ID), Essen (IM) regimen and one week regimen (Thailand).
| Vaccine trials / studies |
No. of subjects enrolled |
RVNA response [ GMC (IU/mL ] |
||||
|---|---|---|---|---|---|---|
| Day 7 |
Day 14 |
Day 28 |
Day 180 |
Day 365 |
||
| Comparing studies using PCECV (Rabipur) | ||||||
| Present study |
38 |
0.27 |
12.01 |
11.30 |
4.33 |
0.72 |
| TRC regimen14 |
58 |
0.34 |
28.5 |
10.9 (Day 30) |
3.0 (Day 90) |
- |
| TRC regimen15 |
55 |
- |
4.3 |
9.0 (Day 30) |
3.7 |
– |
| 4 site regimen16 |
86 |
0.15 |
20.5 |
- |
2.39 (Day 90) |
- |
| Essen regimen14 |
37 |
0.29 |
12.3 |
18.5 (Day 30) |
4.7 (Day 90) |
- |
| Essen regimen17 |
50 |
- |
6.88 |
16.48 |
3.45 |
- |
|
Comparing studies using PVRV (Verorab) | ||||||
| Present study |
40 |
0.27 |
12.21 |
11.46 |
4.32 |
0.75 |
| One week ID regimen (Thailand)3 |
45 |
0.10 |
18.58 |
8.61 |
1.41 |
1.17 (Day 360) |
| Updated TRC regimen13 |
63 |
- |
3.26 3.143.76 |
7.70 7.43–8.36 |
3.57 (Day 90) |
- |
| TRC regimen14 |
59 |
0.32 |
28.9 |
10.9 (Day 30) |
2.7 (Day 90) |
- |
| TRC regimen15 |
50 |
- |
4.6 |
8.7 (Day 30) |
3.6 |
- |
| 4 site regimen16 |
87 |
0.08 |
26.1 |
- |
2.75 (Day 90) |
- |
| Essen regimen13 |
35 |
- |
5.1 |
11.2 |
7.83 (Day 90) |
- |
| Essen regimen17 | 48 | - | 6.65 | 16.43 | 3.71 | - |
Note: GMC: Geometric mean concentration; PCECV = Purified chick embryo cell vaccine (Rabipur); PVRV = Purified vero cell rabies vaccine (Verorab); TRC: Thai Red Cross