Figure 7. Growth of the wild-type, ΔmetQ, ΔmetEF and ΔmetEF/ΔmetQ S. pneumoniae strains in human blood or in human blood supplemented with amino acids.

Data is presented as the mean (SD) fold change in the bacterial CFU per ml at 2 h (clear columns) and at 4 h (grey columns) in human blood (A) or at 4 h (clear columns) and 6 h (grey columns) in human blood supplemented with amino acids (B). P values for the differences between the wild-type and the mutant strains at 4 h (A) and between the ΔmetEF/ΔmetQ strain with and without added methionine at 4 h or 6 h (B) were obtained using ANOVA and post hoc tests, *P<0.05, ** p<0.01. Log¹⁰ bacterial CFU per ml results for each condition are given in figures above the corresponding bar in the graphs.