Table 1. Stage one Test of SNPs in GLC1B-Region Genes for Association with POAG or NTG.
| Genomic Information | POAG | NTG | Control | ||||||
| rs number | Location | Gene Symbol | MAF | Odds ratio (CI) | p value* | MAF | Odds ratio (CI) | p value* | MAF |
| rs741788 | 2p13 | DCTN1 | 0.455 | 1.47 (1.02–2.12) | 0.038 | 0.455 | 1.47 (1.02–2.11) | 0.040 | 0.363 |
| rs909177 | DCTN1 | 0.455 | 1.44 (1.00–2.08) | 0.047 | 0.463 | 1.49 (1.03–2.14) | 0.032 | 0.367 | |
| rs740277 | DCTN1 | 0.455 | 1.44 (1.00–2.08) | 0.047 | 0.463 | 1.49 (1.03–2.14) | 0.032 | 0.367 | |
| rs678350 | 2p13 | HK2 | 0.333 | 1.50 (1.01–2.23) | 0.043 | 0.371 | 1.77 (1.19–2.62) | 0.004 | 0.250 |
| rs651071 | HK2 | 0.199 | 0.60 (0.40–0.92) | 0.018 | 0.256 | 0.84 (0.56–1.25) | 0.383 | 0.292 | |
| rs1807090 | HK2 | 0.268 | 1.59 (1.03–2.44) | 0.034 | 0.238 | 1.35 (0.87–2.10) | 0.181 | 0.188 | |
| rs1239066 | 2p12 | 0.293 | 3.04 (1.95–4.72) | 0.009 | 0.269 | 1.55 (1.01–2.38) | 0.045 | 0.192 | |
| rs53915 | 2p12-p11.1 | CTNNA2 | 0.199 | 0.64 (0.42–0.98) | 0.039 | 0.260 | 0.91 (0.61–1.36) | 0.641 | 0.279 |
| rs1529385 | 2p11.2 | LOC129293 (C2orf89) | 0.053 | 0.39 (0.20–0.77) | 0.005 | 0.087 | 0.66 (0.37–1.20) | 0.173 | 0.125 |
| rs1053561 | 2p11.2 | TGOLN2 | 0.114 | 0.53 (0.32–0.88) | 0.012 | 0.178 | 0.89 (0.56–1.40) | 0.609 | 0.196 |
| rs1562322 | 2p11.2 | LOC51255 (RNF181) | 0.321 | 0.88 (0.61–1.29) | 0.520 | 0.256 | 0.64 (0.43–0.95) | 0.027 | 0.349 |
| rs3024831 | 2p12-p11.2 | SFTPB | 0.250 | 0.92 (0.61–1.38) | 0.675 | 0.190 | 0.65 (0.42–0.99) | 0.045 | 0.267 |
| rs6875 | 2q11.2 | RW1 (TMEM131) | 0.008 | 0.21 (0.05–0.98) | 0.030 | 0.025 | 0.66 (0.23–1.88) | 0.431 | 0.038 |
| rs1982336 | RW1 (TMEM131) | 0.008 | 0.23 (0.05–1.05) | 0.027 | 0.029 | 0.75 (0.28–2.05) | 0.576 | 0.038 | |
| rs718159 | RW1 (TMEM131) | 0.008 | 0.21 (0.05–0.98) | 0.028 | 0.029 | 0.76 (0.28–2.07) | 0.587 | 0.038 | |
| rs222 | 2q11.2 | INPP4A | 0.183 | 0.69 (0.44–1.06) | 0.091 | 0.161 | 0.59 (0.38–0.93) | 0.021 | 0.246 |
| rs1530028 | 2q11.2 | FLJ45273 (LONRF2) | 0.228 | 0.66 (0.44–0.99) | 0.045 | 0.306 | 0.99 (0.67–1.46) | 0.952 | 0.308 |
| rs1030902 | 2q11.2 | ALS2 | 0.225 | 0.65 (0.44–0.98) | 0.039 | 0.314 | 1.03 (0.70–1.51) | 0.892 | 0.308 |
| rs1369482 | 2q11.2 | NPAS2 | 0.244 | 0.65 (0.43–0.96) | 0.030 | 0.298 | 0.85 (0.58–1.24) | 0.398 | 0.333 |
| rs871656 | 2q12 | IL1R1 | 0.337 | 0.70 (0.49–1.01) | 0.058 | 0.322 | 0.66 (0.45–0.95) | 0.025 | 0.421 |
| rs878539 | 2q11.2 | SLC9A2 (NHE2) | 0.463 | 1.52 (1.06–2.18) | 0.024 | 0.422 | 1.28 (0.89–1.85) | 0.185 | 0.363 |
| rs869833 | 2q12.1 | TMEM182 | 0.467 | 1.66 (1.15–2.40) | 0.006 | 0.376 | 1.14 (0.79–1.65) | 0.490 | 0.346 |
| rs960011 | TMEM182 | 0.415 | 0.57 (0.40–0.82) | 0.001 | 0.512 | 0.85 (0.60–1.21) | 0.232 | 0.554** | |
| rs2033008 | 2q12 | NCK2 | 0.293 | 0.76 (0.51–1.11) | 0.147 | 0.252 | 0.62 (0.42–0.91) | 0.015 | 0.354 |
| rs1027003 | 2q12 | 0.110 | 3.16 (1.46–6.88) | 0.002 | 0.058 | 1.58 (0.67–3.71) | 0.295 | 0.038 | |
| rs1474220 | 2q12.3 | GCC2 | 0.106 | 0.59 (0.35–1.00) | 0.050 | 0.136 | 0.79 (0.48–1.30) | 0.353 | 0.167 |
| rs899259 | 2q13 | EDAR | 0.098 | 0.66 (0.38–1.14) | 0.134 | 0.075 | 0.49 (0.28–0.90) | 0.019 | 0.142 |
| rs1509414 | 2q13 | BENE(MALL) | 0.037 | 0.40 (0.18–0.88) | 0.020 | 0.041 | 0.45 (0.21–0.98) | 0.039 | 0.096 |
| rs1567366 | 2q13 | NPHP1 | 0.561*** | 1.34 (0.94–1.92) | 0.105 | 0.576*** | 1.44 (1.01–2.07) | 0.045 | 0.488 |
| rs2119112 | 2q14.2 | MARCO | 0.110 | 0.57 (0.34–0.95) | 0.029 | 0.107 | 0.55 (0.33–0.93) | 0.025 | 0.179 |
*
chi-square test.
**
minor allele frequency in stage 2 control was 0.494.
***
minor allele in control was major allele in POAG and NTG subjects.
MAF; minor allele frequency, CI; confidence interval.