Table 6. Correlation between the POAG or NTG Endophenotypes and NCK2 SNP rs2033008 Screened in Stage Two.
Endophenotype | Age at diagnosis (y.o.) | Maximum IOP* (mmHg) | MD value of the visual field (dB) | |||||||||
Genotype | T/T | T/A | A/A | p value** | T/T | T/A | A/A | p value** | T/T | T/A | A/A | p value** |
POAG | 55.8 | 61.0 | 54.2 | 0.94 | 23.7 | 24.2 | 25.0 | 0.87 | −15.38 | −14.94 | −12.28 | 0.63 |
NTG | 56.8 | 56.0 | 52.2 | 0.70 | 16.7 | 17.0 | 16.0 | 0.79 | −9.83 | −10.95 | −16.28 | 0.05 |
IOP; intraocular pressure (under medication).
Dunnett's test.
A/A is mutant homozygote, T/A is heterozygote, and T/T is wild homozygote.