Table 2. Serotype distribution of pneumococci isolated from 818 episodes of acute otitis media from children less than 5 years of age in Gipuzkoa, Northern Spain (1999–2010).
| Serotype | 1999–2001 | 2002–2004 | 2005–2007 | 2008–2010 | Total | |||||
| n | % | n | % | n | % | n | % | n | % | |
| 4 | 1 | 0.9 | 1 | 0.5 | 2 | 0.8 | 0 | 4 | 0.5 | |
| 6B | 15 | 12.8 | 6 | 2.9 | 4 | 1.5 | 0 | 25 | 3.1 | |
| 9V | 1 | 0.9 | 2 | 1.0 | 4 | 1.5 | 1 | 0.4 | 8 | 1.0 |
| 14 | 20 | 17.1 | 15 | 7.2 | 15 | 5.7 | 1 | 0.4 | 51 | 6.2 |
| 18C | 2 | 1.7 | 2 | 1.0 | 2 | 0.8 | 0 | 6 | 0.7 | |
| 19F | 24 | 20.5 | 38 | 18.2 | 9 | 3.4 | 3 | 1.3 | 74 | 9.0 |
| 23F | 10 | 8.5 | 9 | 4.3 | 6 | 2.3 | 0 | 25 | 3.1 | |
| PCV7 1 | 73 | 62.4 | 73 | 34.9 | 42 | 15.8 | 5 | 2.2 | 193 | 23.6 |
| 1 | 1 | 0.9 | 3 | 1.4 | 10 | 3.8 | 7 | 3.1 | 21 | 2.6 |
| 5 | 0 | 0 | 2 | 0.8 | 5 | 2.2 | 7 | 0.9 | ||
| 7F | 1 | 0.9 | 7 | 3.3 | 8 | 3.0 | 9 | 4.0 | 25 | 3.1 |
| PCV10 2 | 2 | 1.7 | 10 | 4.8 | 20 | 7.5 | 21 | 9.3 | 53 | 6.5 |
| 3 | 6 | 5.1 | 14 | 6.7 | 38 | 14.3 | 34 | 15.0 | 92 | 11.2 |
| 6A | 2 | 1.7 | 8 | 3.8 | 9 | 3.4 | 4 | 1.8 | 23 | 2.8 |
| 19A | 21 | 17.9 | 53 | 25.4 | 67 | 25.3 | 86 | 37.9 | 227 | 27.8 |
| PCV13 3 | 29 | 24.8 | 75 | 35.9 | 114 | 43.0 | 124 | 54.6 | 342 | 41.8 |
| 6C | 0 | 1 | 0.5 | 3 | 1.1 | 10 | 4.4 | 14 | 1.7 | |
| 8 | 0 | 2 | 1.0 | 2 | 0.8 | 2 | 0.9 | 6 | 0.7 | |
| 9N | 0 | 1 | 0.5 | 1 | 0.4 | 1 | 0.4 | 3 | 0.4 | |
| 10 | 0 | 7 | 3.3 | 4 | 1.5 | 4 | 1.8 | 15 | 1.8 | |
| 11 | 1 | 0.9 | 9 | 4.3 | 9 | 3.4 | 8 | 3.5 | 27 | 3.3 |
| 12 | 0 | 0 | 1 | 0.4 | 3 | 1.3 | 4 | 0.5 | ||
| 15A | 0 | 0 | 3 | 1.1 | 3 | 1.3 | 6 | 0.7 | ||
| 15B | 0 | 4 | 1.9 | 15 | 5.7 | 6 | 2.6 | 25 | 3.1 | |
| 16F | 1 | 0.9 | 3 | 1.4 | 7 | 2.6 | 6 | 2.6 | 17 | 2.1 |
| 21 | 1 | 0.9 | 2 | 1.0 | 10 | 3.8 | 4 | 1.8 | 17 | 2.1 |
| 22F | 1 | 0.9 | 4 | 1.9 | 6 | 2.3 | 3 | 1.3 | 14 | 1.7 |
| 23A | 1 | 0.9 | 2 | 1.0 | 4 | 1.5 | 2 | 0.9 | 9 | 1.1 |
| 23B | 0 | 2 | 1.0 | 3 | 1.1 | 3 | 1.3 | 8 | 1.0 | |
| 31 | 0 | 0 | 1 | 0.4 | 5 | 2.2 | 6 | 0.7 | ||
| 33 | 1 | 0.9 | 3 | 1.4 | 3 | 1.1 | 4 | 1.8 | 11 | 1.3 |
| 35 | 4 | 3.4 | 0 | 3 | 1.1 | 7 | 3.1 | 14 | 1.7 | |
| 38 | 0 | 0 | 1 | 0.4 | 0 | 1 | 0.1 | |||
| Other4 | 0 | 9 | 4.3 | 9 | 3.4 | 6 | 2.6 | 24 | 2.9 | |
| NT | 3 | 2.6 | 2 | 1.0 | 4 | 1.5 | 0 | 9 | 1.1 | |
| Non PCV13 | 13 | 11.1 | 51 | 24.4 | 89 | 33.6 | 77 | 33.9 | 230 | 28.1 |
| Total episodes | 117 | 209 | 265 | 227 | 818 | |||||
1
PCV7: number of isolates of serotypes included in the PCV7: serotypes 4, 6B, 9V, 14, 18C, 19F and 23F.
2
PCV10: number of isolates of serotypes 1, 5, and 7F, included in the PCV10 but not in the PCV7.
3
PCV13: number of isolates of serotypes 3, 6A, and 19A, included in the PCV13 but not in the PCV10.
4
Non-PCV13 serotype (2, 7A, 13, 17F, 18F, 19B, 24, 25, 28, 29, 34, 36, 39,41,47) who total number was less than 4 were grouped as “Others”.