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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: DNA Repair (Amst). 2012 Dec 17;12(2):128–139. doi: 10.1016/j.dnarep.2012.11.005

Figure 6.

Figure 6

A model of one of the pathways of replication fork recovery from HU-induced arrest. An arrested fork regresses, forming a daughter/daughter strand duplex. This duplex is resected and/or unwound to expose a 3′ single-stranded tail. WRN and BLM can perform unwinding or assist resection. The tail invades the parental duplex in a RAD51-dependent manner, forming a D-loop. Extension of a D-loop may be stimulated by WRN. Note that if resection/unwinding of the daughter/daughter duplex is incomplete, remaining linkage of paired strands can persist after the D-loop is converted into a reactivated fork, and even after S phase is completed. At mitosis, this hemicatenation between sister chromatids can be dissolved by BLM (in complex with topoIIIα and RMIs).