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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Biomaterials. 2012 Dec 20;34(9):2327–2339. doi: 10.1016/j.biomaterials.2012.11.053

Fig. 7.

Fig. 7

The effect of different formulations of GemHCl or GemC18 on RRM1 expression and dNTP and dFdCTP levels in TC-1-GR cells. (A) Immunoblotting analysis of RRM1 expression in TC-1-GR cells treated with GemHCl, GemC18, GemC18-loaded PAC, PHC-1, or PHC-2 micelles. Untreated cells were used as the control (Shown are typical data from more than 3 replicates). (B) Cellular dNTP level after treatment with GemHCl, GemC18, GemC18-loaded PAC, PHC-1, or PHC-2 micelles (n = 3). Untreated cells were used as the control. a, P < 0.05 vs. control; b, P < 0.05 vs. GemHCl; c, P < 0.01 vs. GemHCl; d, P < 0.05 vs. control. (C) Cellular dFdCTP level after treatment with GemHCl, GemC18, GemC18-loaded PAC, PHC-1, or PHC-2 micelles (n = 3). e, P < 0.01 vs. GemHCl and GemC18; f, P < 0.01 vs. others. (D) The ratio of dFdCTP to total dNTPs in TC-1-GR cells after treatment with GemHCl, GemC18, GemC18-loaded PAC, PHC-1, or PHC-2 micelles (n = 3). g, P < 0.01 vs. others; h, P < 0.05 vs. others.