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IC50 values of various GemHCl and GemC18 formulations in TC-1 and TC-1-GR cells (n = 4–5) and the calculated resistance indices
| IC50
|
Resistance index | ||
|---|---|---|---|
| TC-1 (nM) | TC-1-GR (μM) | ||
| GemHCl | 17.8 ± 6.0 | 6.48 ± 0.21 | 364.1 |
| GemC18 in solution | 75.2 ± 4.9 | 10.50 ± 1.12 | 139.5 |
| GemC18-PAC micelles | 120.7 ± 32.8 | 12.23 ± 0.75 | 101.3 |
| GemC18-PHC-1 micelles | 85.3 ± 4.9 | 4.88 ± 2.93 | 57.2 |
| GemC18-PHC-2 micelles | 82.9 ± 4.2 | 0.86 ± 0.03 | 10.4 |
