Table 3.
Association of Cardiometabolic Risk Profile (CMRP)1 with patient complexity, history of coronary heart disease, regimen intensity and medication problems with adherence, results from multiple regression analysis2
| Model 1: Patient complexity + History of CHD + Regimen Complexity + Adjustors | Model 2: Model 1 + Problems with adherence | |||
|---|---|---|---|---|
| Beta estimate (± 95% CI) | p-value | Beta estimate (±95% CI) | p-value | |
| Patient complexity3 | 1.4 (0.5, 2.4) | .003 | 0.9 (-0.4, 2.0) | .061 |
| History of CHD4 | -3.4 (-6.1,-0.8) | .010 | -3.2 (-5.8,-0.6) | .017 |
| Regimen intensity5 | 0.2 (-0.2, 0.7) | .32 | 0.2 (-0.2, 0.7) | .31 |
| Problems with adherence to medication regimen6 | -- | 3.3 (1.2, 5.4) | .002 | |
| R2 | .098 | <.001 | .106 | .002 |
Cardiometabolic Risk Profile (CMRP) is a composite measure of cardiovascular event risk computed as the mean proportional distance ([measured value/target value]-1) above or below clinical targets for hemoglobin A1c level (<7%), systolic blood pressure (<130 mm Hg) and LDL cholesterol (<100 mg/dL). A score of zero was equivalent to all three risk factors being at target values. Lower CMRP scores reflected better control of risk factors. Laboratory values, regimen intensity and history of coronary heart disease were abstracted from medical records.
Results from regression models adjusted for sex, education, ethnicity, age at diagnosis of diabetes and diabetes duration. Model 2 includes all the independent variables and covariates included in Model 1 plus problems with adherence to medication regimen.
Measured using the 51-item Potential for Benefit Scale (PBS).
Myocardial infarction or coronary heart disease noted in the medical chart
The number of classes of medications for which the patient had a prescription.
Problems with adherence to medication regimen was based on responses to a 13-item scale assessing patient-initiated deviations from the prescribed treatment plan.