Table III.
Post-HCT protein concentrations influencing aGVHD risk.
| Plasma Protein | Characteristic | Impact | Study population (n) | Reference |
|---|---|---|---|---|
| CD8 | CD8 >129 u/ml at day 15 | ↑ aGVHD | Related, Unrelated (61) | (August, et al 2011) |
|
| ||||
| CD40L | Plasma concentrations post-transplant | NSA | Related, Unrelated (61) | (Ambruzova, et al 2009) |
|
| ||||
| IL2R | IL2R >22 ng/ml at day 15 | ↑ aGVHD | Related, Unrelated (61) | (August, et al 2011) |
|
| ||||
| IL6 | Increased IL6 levels from day +1 until day +21 | ↑ aGVHD | Related(101) | (Liu, et al 2010) |
| Plasma IL6 concentrations during conditioning | NSA | Related, Unrelated (112) | (Remberger, et al 1995) | |
|
| ||||
| IL7 | Increased day 7 and/or day 14 IL7 | ↑ aGVHD | Related (31) | (Dean, et al 2008) |
| Day 14 IL7 >11.9 pg/ml | ↑ aGVHD | Related, Unrelated; Full intensity (40) | (Thiant, et al 2010) | |
| Day 30 IL7 >5.9 pg/ml | ↑ aGVHD | Related, Unrelated; Reduced intensity (45) | (Thiant, et al 2011) | |
|
| ||||
| sBAFF | sBaff >43 pg/ml prior to conditioning and at days 0, 7 and 14 | ↓ aGVHD | Related, Unrelated; Full intensity (45) | (Cho, et al 2010) |
|
| ||||
| TNFα | Higher TNFα levels during conditioning | ↑ aGVHD | Related, Unrelated (112) | (Remberger, et al 1995) |
| Increased TNFα transcription | ↑ aGVHD; | Related, Unrelated (23) | (Ritchie, et al 2005) | |
| Day 7/Baseline TNFR1 ratio >2.5 | HR=2.4 | Related, Unrelated; Full intensity (438) | (Choi, et al 2008) | |
| ↑ aGVHD severity | Related, Unrelated; Full intensity; Paediatric (82) | (Kitko, et al 2008) | ||
| High Day 7/Baseline TNFR1 ratio | ↑ aGVHD | Related, Unrelated; Reduced intensity (106) | (Willems, et al 2010) | |
| TNFR1 >1040 pg/ml at day 15 | ↑ aGVHD | Related, Unrelated (61) | (August, et al 2011) | |
| Increased TNFα levels from day +1 until day +21 | ↑ aGVHD | Related (101) | (Liu, et al 2010) | |
*
Relative risk (RR), hazard ratio (HR) or odds ratio (OR) provided when reported, otherwise increased or decreased risk is reported. Confidence intervals, when provided, are in brackets.
aGVHD - acute graft-versus-host disease; NSA – No significant association; RR – Relative risk; HR – Hazard ratio; OR – Odds ratio