Figure 10.

Potentiation of striatal dopamine terminal loss in 6 month old transgenic (TG) rats exposed to low-dose rotenone. Animals expressing E46K-mutated α-synuclein exhibit decreased striatal tyrosine hydroxylase immunofluorescence at subthreshold rotenone exposure (2.5 mg/kg/day). A typical striatal lesion is observed in E46K animals, overt lesions are not typically present wild-type (WT; littermate controls) animals at this rotenone dose. n = 10/group. ***p<0.001, Student’s t-test.