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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Exp Neurol. 2012 Nov 12;240:44–56. doi: 10.1016/j.expneurol.2012.11.007

Figure 4.

Figure 4

α-Synuclein accumulation and aggregation in the substantia nigra. Animals (12-month old) expressing E46K-mutated α-synuclein exhibit overt accumulation and aggregation of α-synuclein. Low magnification images show diffuse accumulation of both total and aggregated human α-synuclein. High magnification images show both neuropil (likely in processes) and intracellular accumulation and aggregation in nigral dopamine neurons (tyrosine hydroxylase +, TH). The morphology of E46K neurons is also altered compared to wild-type (WT; littermate controls), where the cell membrane appears to be undergoing fragmentation (indicated by arrows).