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Striatal serotonin (5-HT) and serotonin metabolite levels in 12 month-old rats. Transgenic (TG) rats expressing E46K mutated α-synuclein did not exhibit differences in basal serotonin levels compared to wild-type (WT; littermate controls). However, TG rats exhibited decreased 5-HT metabolite levels. 5-Hydroxyindole-3-acetic acid (5-HIAA) was significantly reduced in TG rats. 5-HT turnover (5-HIAA/5-HT) was also significantly reduced. **p<0.01, Student’s t-test. n = 10/group.
