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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: DNA Repair (Amst). 2012 Dec 11;12(2):92–96. doi: 10.1016/j.dnarep.2012.11.001

Figure 1. Polymerase-specific mutator effects in exo1Δ strains.

Figure 1

Spontaneous mutation rates (with 95% confidence intervals) to (A) 5-FOA resistance and (B) canavanine resistance. Differences in mutation rates between the pol1-L868M exo1Δ and other two double mutant strains are statistically significant (p <0.05), as indicated by asterisks. Deleting EXO1 results in a 46-fold and a 12-fold increase in mutation rates to 5-FOA resistance compared to the corresponding single pol mutants; pol1-L868M and pol3-L612M, respectively. For canavanine resistance, deletion of EXO1 in a pol mutator background causes a mutation rate increase of 52-fold and 14-fold, compared to pol1-L868M and pol3-L612M, respectively.