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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Nat Immunol. 2012 Dec 23;14(2):136–142. doi: 10.1038/ni.2508

Figure 5. IFN-γ mediates loss of Paneth cells.

Figure 5

(a) WT mice were treated with isotype control (IC), α-IFN-γ, α-CD4, or α-CD8 antibodies and then infected orally with 20 cysts per mouse of the ME49 strain of T. gondii. Histological analyses of Paneth cells in small intestines were performed on day 7 post-infection. (b) qRT-PCR analysis of Lyz1, Defcr1 (alpha-defensin-1), Defa-rs1, Defa21, CR2, and RegIII-γ were measured in the small intestines of naïve (blue) or T. gondii-infected WT mice treated with IC, α-IFN-γ, α-CD4, or α-CD8 antibodies (purple). * P< 0.05; ** P< 0.01. The results are representative of three independent experiments, each involving 4–7 mice per group.