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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Bone. 2012 Sep 24;54(2):250–257. doi: 10.1016/j.bone.2012.09.016

Figure 3. PPR signaling modulates the endocrine and auto/paracrine function of osteocytes by regulating FGF23 expression.

Figure 3

cAMP elevation in vivo by a constitutively active PPR or in vitro by the PPR ligands PTH and PTHrP increases FGF23 in a Wnt-dependent manner. A simultaneous increase in GALNT3 stabilizes FGF23, leading to increased intact FGF23 in the circulation as well as locally in bone. Binding of FGF23 to the FGFR1/KLOTHO receptor complex expressed in osteocytes and osteoblasts activates intracellular signaling.