Skip to main content
. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Neurogastroenterol Motil. 2013 Jan 2;25(2):e101–e113. doi: 10.1111/nmo.12059

Figure 2.

Figure 2

Muscle tone does not alter colonic responses to stretch. (A) Shows membrane potential and isometric force in response to a stretch ramp under control conditions. Application of the stretch ramp (arrows) produced membrane hyperpolarization (dashed line) and inhibition of AP complexes. (B) In the presence of nifedipine, AP complexes were abolished but application of the stretch ramp still produced membrane hyperpolarization (dashed line) in response to stretch dependent changes in muscle length. Nifedipine also increased the compliance of the colonic tissue. In this example, under control conditions 5 mN of force was reached in 335 seconds (A) and after nifedipine 5mN of force was reached in 372 seconds (B).