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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Biol Psychiatry. 2012 Sep 18;73(3):249–255. doi: 10.1016/j.biopsych.2012.07.034

Figure 2.

Figure 2

Time course and severity of acute ethanol withdrawal measured in adult male C57BL/6J (B6) and DBA/2J (D2) mice during the first 25 h after termination of the passive intragastric dosing procedure shown in Figure 1. Withdrawal severity was indexed by handling-induced convulsions (HICs) scored on a scale from 0 (no convulsion) to 7 during the habituation baseline (B) session (before induction of dependence) and at various times after the onset of the last passive ethanol infusion (n = 11/group). Withdrawal severity peaked about 7-9 h after onset of the last infusion, reaching a significantly higher level in D2 mice than in B6 mice. A Strain × Time ANOVA yielded significant main effects of Strain [F(1,20) = 23.1, p < .0001] and Time [F(14,280) = 17.5, p < .0001] as well as a significant interaction [F(14,280) = 10.4, p < .0001]. Error bars depict SEM.