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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Biol Psychiatry. 2012 Sep 18;73(3):249–255. doi: 10.1016/j.biopsych.2012.07.034

Figure 5.

Figure 5

Effect of inserting an abstinence period between the no-choice and choice ethanol self-infusion phases in D2 mice (Experiment 3). (A) Ethanol-dependent mice received daily passive infusions of ethanol for 5 days (P1-P5) as shown in Figure 1. Delays of 0, 1, or 5 days separated the second no-choice self-infusion session from the first choice self-infusion session for Groups 0, 1, and 5, respectively. (B) Daily mean ethanol intakes (g/kg/d) during the no-choice (N1-N2) and choice (C1-C5) self-infusion phases. (C) Mean ethanol intakes (g/kg/d) during the 2 no-choice self-infusion sessions (left panel) and during the 5 choice self-infusion sessions (right panel) (n = 11-13/group). (D) Mean S+ preference ratios (S+ licks divided by total of S+ and S- licks) during the choice self-infusion phase (dashed line = no preference). Error bars depict SEM.