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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: J Immunol. 2012 Dec 28;190(3):1264–1275. doi: 10.4049/jimmunol.1202012

Fig.8. Summary of MKK3 Signaling.

Fig.8

We postulate that endothelial MKK3 is required for LPS-induced mitochondrial ROS generation, IKKα/β phosphorylation, NF-kB and AP-1 activation and ICAM-1 expression, ultimately leading to inflammatory recruitment.