Table V.
Residue-specific cutoffs and global cutoff for dPSSM, biological assembly surface area, and monomer surface area
| Biological assembly surface area* | Monomer surface area* | dPSSM score | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Wildtype | Cutoff | Mutant | Cutoff | Wildtype | Cutoff | Mutant | Cutoff | Wildtype | Cutoff | Mutant | Cutoff |
| I | 11.7 | L | 12.8 | F | 10.9 | L | 10.9 | V | 2.4 | I | 2.4 |
| M | 12.3 | T | 17.5 | Y | 11.7 | M | 13.8 | A | 2.8 | M | 2.6 |
| C | 13.2 | I | 18.0 | I | 12.5 | W | 14.5 | K | 2.8 | N | 2.9 |
| V | 15.0 | W | 18.1 | M | 12.5 | V | 15.0 | E | 3.0 | P | 3.1 |
| F | 15.1 | Y | 19.1 | V | 15.5 | I | 15.8 | I | 3.0 | K | 3.2 |
| A | 15.5 | N | 21.0 | C | 17.2 | F | 17.7 | Q | 3.0 | V | 3.2 |
| Y | 16.0 | R | 21.1 | H | 17.6 | G | 20.2 | S | 3.0 | T | 3.3 |
| H | 17.7 | M | 21.2 | A | 19.0 | R | 21.9 | T | 3.1 | Q | 3.5 |
| L | 20.5 | F | 21.8 | Q | 21.9 | Y | 22.0 | L | 3.3 | E | 3.6 |
| N | 22.2 | S | 22.3 | L | 22.1 | H | 22.3 | M | 3.6 | A | 3.8 |
| R | 22.8 | V | 22.4 | T | 22.2 | T | 23.0 | R | 3.9 | F | 3.8 |
| Q | 23.0 | H | 22.5 | R | 23.0 | N | 23.7 | N | 4.0 | H | 3.9 |
| T | 24.1 | A | 23.3 | S | 25.8 | S | 24.2 | D | 4.5 | D | 3.9 |
| S | 25.4 | C | 24.5 | K | 26.6 | P | 25.0 | F | 4.9 | R | 4.5 |
| K | 27.0 | D | 24.6 | W | 27.0 | Q | 25.0 | Y | 5.2 | L | 4.6 |
| G | 27.4 | Q | 24.8 | G | 27.2 | D | 26.1 | G | 5.3 | S | 4.7 |
| P | 28.0 | P | 25.0 | N | 27.5 | A | 27.5 | H | 5.5 | G | 5.2 |
| W | 29.0 | G | 25.9 | P | 28.2 | K | 27.8 | P | 7.1 | Y | 5.9 |
| E | 30.0 | K | 26.0 | D | 30.5 | E | 30.8 | C | 7.4 | C | 6.0 |
| D | 31.8 | E | 28.9 | E | 33.2 | C | 34.8 | W | 9.1 | W | 6.0 |
|
| |||||||||||
| Global cutoff | 22.1 | Global cutoff | 22.9 | Global cutoff | 3.7 | ||||||
*
Surface area in Å2.