Table VII.

The performance of SVMs on balanced data sets

Feature	TPR	TNR	PPV	NPV	BACC
Surface area of monomer	63.9	65.4	64.9	64.5	64.7
Surface area of BA	73.5	62.2	66.1	70.1	67.9
Surface area of BA and monomer	75.5	60.0	65.4	71.0	67.8
BA surface area & PSSM score	73.7	80.2	78.9	75.4	77.0
BA surface area & conservation score	79.9	72.4	74.3	78.3	76.1
PSSM score & conservation score	83.6	76.6	78.1	82.4	80.1
BA surface area & PSSM score & conservation score	82.9	80.2	80.7	82.4	81.5
Two sequence and two structural features	83.0	80.5	81.0	82.6	81.7
Same four features on balanced independent testing dataset	82.7	78.3	79.2	81.9	80.5

All results except the last line are based on 10-fold cross-validation (training on 90% and testing on the remaining 10%, and performing this procedure for each 10% of the data). The last line provides results trained on all the mutations in the cross-validation set but tested on an independent data set.