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. Author manuscript; available in PMC: 2013 Jan 23.
Published in final edited form as: Pediatr Crit Care Med. 2010 Jan;11(1):109–116. doi: 10.1097/PCC.0b013e3181b01042

Figure 4.

Figure 4

Nonpharmacologic hypothermia increases plasma interleukin (IL)-6 and IL-10. Juvenile mice were sham treated (n = 12) or given lipopolysaccharide (LPS) 1 μg/g IP (n = 10). All mice were then placed in a cool chamber with an ambient temperature of 4°C for 6 hrs. Temperature was monitored every 2 hrs and plasma was collected at 6 hrs for measurements of IL-6 and IL-10. A) Mean temperature with sham or LPS treatment in cool chamber. B, C) Correlation of plasma IL-6 and IL-10 to body temperature in LPS-treated mice (Spearman IL-6 r = −.58 (p = .0765) and IL-10 r = −.49 (p = .1482).