Table 1.

Model parameters

Parameter	Value	Units	Description
${\rho }^{F1}$	5	mM	Concentration of F1F0-ATPase
${\rho }^{res}$	0.2	mM	Concentration of electron carriers (respiratory complexes I-III-IV)
${\rho }^{res\left(SDH\right)}$	0.017	mM	Concentration of electron carriers (respiratory complexes II-III-IV)
[Pi]i	3	mM	Extra-matrix phosphate concentration
[AcCoA]	1	mM	Acetyl CoA concentration
[GLU]	30	mM	Glutamate concentration
gH	2 × 10−6	mM ms−1 mV−1	H+ conductance of inner membrane
$k_{cat}^{CS}$	2.35 × 10−4	ms−1	Catalytic constant of CS
$k_f^{ACO}$	1.17 × 10−4	ms−1	Forward rate constant of ACO
$k_{cat}^{IDH}$	11.9	ms−1	Rate constant of IDH
$k_{cat}^{KDGH}$	1.32 × 10−2	ms−1	Rate constant of KGDH
$k_f^{SL}$	2.80 × 10−2	mM-1ms−1	Forward rate constant of SL
$k_f^{FH}$	8.30 × 10−3	ms−1	Forward rate constant for FH.
$k_{cat}^{MDH}$	1.24 × 10−1	ms−1	Rate constant of MDH
$k_f^{AAT}$	2.14 × 10−2	ms−1	Forward rate constant of AAT
$c_{PiC}$	4.90	mg protein ml−1	PiC concentration
Nai	11	mM	Extra-matrix Na+
$V_{\max }^{uni}$	4.46 × 10−3	mM ms−1	Vmaxuniporter Ca2+ transport
$V_{\max }^{NaCa}$	1.83 × 10−4	mM ms−1	Vmax of Na+/Ca2+ exchanger
VmaxANT	3.15	mM ms−1	Maximal rate of the ANT
${\text{E}}_{\text{MnSOD}}^{\text{T}}$	3 × 10−4	mM	Mitochondrial concentration of MnSOD
${\text{E}}_{\text{MnSOD}}^{\text{T}}$	2.4 × 10−4	mM	Extra-matrix concentration of Cu,ZnSOD
${\text{E}}_T^{Tr\text{xR}2\text{m}}$	3.5 × 10−4	mM	Mitochondrial concentration of TrxR2
${\text{E}}_T^{Tr\text{xR}i}$	3.5 × 10−4	mM	Extra-matrix concentration of TrxR
$E_T^{Prx3m}$	3 × 10−3	mM	Mitochondrial concentration of thioredoxin peroxidase (Prx)
$E_T^{Prx3i}$	1 × 10−1	mM	Extra-matrix concentration of thioredoxin peroxidase (Prx)
$E_T^{GPXm}$	1 × 10−4	mM	Mitochondrial concentration of glutathione peroxidase (GPX)
$E_T^{GPXi}$	5 × 10−5	mM	Extra-matrix concentration of GPX
${\text{E}}_{\text{T}}^{\text{GRm}}$	9 × 10−4	mM	Mitochondrial concentration of GR
${\text{E}}_{\text{T}}^{\text{GRi}}$	9 × 10−4	mM	Extra-matrix concentration of GR
$E_{CAT}^T$	1 × 10−6	mM	Extra-matrix concentration of CAT