. 2013 Jan 22;104(2):332–343. doi: 10.1016/j.bpj.2012.11.3808

Table 2.

Quantitative comparison between experimental and modeling results of respiration, maximal H₂O₂ emission (after inhibition of GSH/Trx systems), ΔΨ_m and NADH in isolated heart mitochondria from guinea pig

Variable	Experimental^∗		Model
	Guinea pig		Simulations
	St 4	St 3	St 4	St 3
Respiration	46 ± 2.6	152 ± 8.5	18.0	56.5
(nmol/mg prot/min)	46 ± 2.6	152 ± 8.5	18.0	56.5
H₂O₂ emission	0.56 ± 0.01	0.48 ±0.06	0.32^†	0.29^†
(nmol/mg prot/min)	0.56 ± 0.01	0.48 ±0.06	0.32^†	0.29^†
% respiratory flux as H₂O₂ emission	0.74	0.29	1.8	0.8
ΔΨ_m (mV)	167 ± 7	142 ± 2	200	180
NADH (%)	98 ± 4	78 ± 5	98	65

^∗

Aon et al. (24).

^†

Total inhibition of glutathione reductase and thioredoxin reductase was achieved by setting the parameters GRm, GR, Trxm, and Trx at a concentration of 10⁻⁹ mM.