Table 1.
Patient characteristics
| NSGO/EORTC-study | MaNGO ILIADE III-study | Total n (%) | |||
|---|---|---|---|---|---|
| RT n (%) | RT-CT n (%) | RT n (%) | RT-CT n (%) | ||
| Randomization | 191 | 187 | 76 | 80 | 534 |
| Age | |||||
| Median (range) | 64 (44-79) | 64 (38-83) | 59 (42-78) | 58 (39-77) | 62(8-83) |
| FIGO stage | |||||
| IA | 27 (14) | 17 (9.1) | 0 | 0 | 44 (8.2) |
| IB | 47 (25) | 62 (33) | 0 | 0 | 109 (20) |
| IC | 98 (51) | 92 (49) | 0 | 0 | 190 (36) |
| II | 2 (1.0) | 3 (1.6) | 0 | 0 | 5 (0.94) |
| IIA | 10 (5.2) | 7 (3.7) | 0 | 1 (1.3) | 18 (3.4) |
| IIB | 0 | 2 (1.1) | 22 (29) | 29 (36) | 53 (10) |
| IIIA | 2 (1.0) | 1 (0.53) | 19 (25) | 18 (23) | 40 (7.5) |
| IIIB | 0 | 0 | 0 | 1 (1.3) | 1 (0.19) |
| IIIC | 1 (0.52) | 1 (0.53) | 32 (42) | 31 (39) | 65 (12) |
| Unknown | 4 (2.1) | 2 (1.1) | 3 (3.9) | 0 | 9 (1.7) |
| Pelvic Lymphadenectomy | |||||
| No | 33 (17) | 37 (20) | 32 (42) | 44 (55) | 146 (27) |
| Yes | 28a (15) | 35b (19) | 41c (54) | 36d (45) | 140 (26) |
| Unknown | 130 (68) | 115 (61) | 3 (3.9) | 0 | 248 (46) |
| Vaginal brachytherapy | |||||
| No | 106 (56) | 96 (51) | 43 (57) | 46 (58) | 291 (54) |
| Yes | 75 (39) | 82 (44) | 21 (28) | 25 (31) | 203 (38) |
| Unknown | 10 (5.2) | 9 (4.8) | 12 (16) | 9 (11) | 40 (7.5) |
| Grade | |||||
| Grade 1 | 19 (10) | 15 (8.0) | 3 (4.0) | 7 (8.8) | 44 (8.2) |
| Grade 2 | 36 (19) | 31 (17) | 36 (47) | 46 (58) | 149 (28) |
| Grade 3 | 92 (48) | 108 (58) | 34 (45) | 27 (34) | 261 (49) |
| Not assigned or unknown e | 44 (23) | 33 (18) | 3 (3.9) | 0 | 80 (15) |
| Cell type | |||||
| Endometrioid | 112 (59) | 116 (62) | 72 (95) | 77 (96) | 377 (71) |
| Adenosquamous | 3 (1.6) | 4 (2.1) | 0 | 0 | 7 (1.3) |
| Serous | 40 (21) | 34 (18) | 0 | 1 (1.3) | 75 (14) |
| Clear cell | 36 (19) | 30 (16) | 0 | 1 (1.3) | 67 (12) |
| Anaplastic | 0 | 2 (1.1) | 1 (1.3) | 1 (1.3) | 4 (0.75) |
| Unknown | 0 | 1 (0.53) | 3 (3.9) | 0 | 4 (0.75) |
| Ploidy | |||||
| Non-diploid | 59 (31) | 63 (34) | 0 | 0 | 122 (23) |
| Diploid | 37 (19) | 38 (20) | 0 | 0 | 75 (14) |
| Polyploid | 3 (1.6) | 7 (3.7) | 0 | 0 | 10 (1.9) |
| Unknown | 92 (48) | 79 (42) | 76 (100) | 80 (100) | 327 (61) |
a
Eight of 28 patients also underwent para-aortal LA
b
Six of 35 patients also underwent para-aortal LA
c
Seven of 41 patients also underwent low para-aortal LA and 6 high para-aortal LA
d
Seven of 36 patients also underwent low para-aortal LA and 3 high para-aortal LA
e
Of the 80 with grade not assigned or unknown, 30 had serous, 36 clear cell carcinomas, and one had anaplastic carcinoma
Abbreviations: FIGO: International Federation of Gynaecology and Obstetrics, RT: radiotherapy, RT-CT: sequential radiotherapy and chemotherapy