Table 3.
NSGO-EC-9501/EORTC-55991 (RT n=191, RT-CT n=187) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
End-point | Events | HR | 95% CI | P | 5-yr probability of survival |
|||||
RT | % | RT-CT | % | Total | RT | RT-CT | ||||
PFS | 50 | 26 | 35 | 19 | 85 | 0.64 | 0.41-0.99 | 0.04 | 0.72 | 0.79 |
OS | 40 | 21 | 28 | 15 | 68 | 0.66 | 0.40-1.08 | 0.10 | 0.76 | 0.83 |
CSS | 34 | 18 | 19 | 10 | 53 | 0.51 | 0.28-0.90 | 0.02 | 0.79 | 0.88 |
MaNGO ILIADE III (RT n=76, RT-CT n=80) | ||||||||||
PFS | 26 | 34 | 18 | 23 | 44 | 0.61 | 0.33-1.12 | 0.10 | 0.61 | 0.74 |
OS | 17 | 22 | 14 | 18 | 31 | 0.74 | 0.36-1.52 | 0.41 | 0.73 | 0.78 |
CSS | 15 | 20 | 11 | 14 | 26 | 0.65 | 0.30-1.44 | 0.29 | 0.76 | 0.82 |
POOLED NSGO-EC-9501/EORTC-55991+MaNGO ILIADE III (RT n=267, RT-CT n=267) | ||||||||||
PFS | 76 | 28 | 53 | 20 | 129 | 0.63 | 0.44-0.89 | 0.009 | 0.69 | 0.78 |
OS | 57 | 21 | 42 | 16 | 99 | 0.69 | 0.46-1.03 | 0.07 | 0.75 | 0.82 |
CSS | 49 | 18 | 30 | 11 | 79 | 0.55 | 0.35-0.88 | 0.01 | 0.78 | 0.87 |
NSGO-EC-9501/EORTC-55991 endometrioid carcinoma (RT n=115, RT-CT n=120) | ||||||||||
PFS | 29 | 25 | 19 | 16 | 48 | 0.50 | 0.27-0.95 | 0.03 | 0.73 | 0.83 |
OS | 25 | 22 | 15 | 13 | 40 | 0.55 | 0.28-1.09 | 0.08 | 0.75 | 0.86 |
CSS | 22 | 19 | 11 | 9 | 33 | 0.42 | 0.19-0.93 | 0.03 | 0.76 | 0.92 |
NSGO-EC-9501/EORTC-55991 serous and clear cell carcinoma (RT n=76, RT-CT n=64) | ||||||||||
PFS | 21 | 28 | 16 | 25 | 37 | 0.83 | 0.42-1.64 | 0.59 | 0.71 | 0.72 |
OS | 15 | 20 | 13 | 20 | 28 | 0.94 | 0.42-2.08 | 0.88 | 0.78 | 0.77 |
CSS | 12 | 16 | 8 | 13 | 20 | 0.71 | 0.26-1.90 | 0.49 | 0.82 | 0.85 |
POOLED NSGO-EC-9501/EORTC-55991+MaNGO ILIADE III endometrioid carcinoma (RT n=187, RT-CT n=197) | ||||||||||
PFS | 54 | 29 | 35 | 18 | 89 | 0.53 | 0.34-0.83 | 0.005 | 0.69 | 0.80 |
OS | 41 | 22 | 27 | 14 | 68 | 0.60 | 0.36-1.00 | 0.05 | 0.74 | 0.84 |
CSS | 36 | 19 | 21 | 11 | 57 | 0.51 | 0.29-0.91 | 0.02 | 0.77 | 0.87 |
Abbreviations: CI: confidence interval, CSS cancer-specific survival, HR: hazard ratio, OS: overall survival, PFS: progression-free survival, RT: radiotherapy, RT-CT: sequential radiotherapy and chemotherapy .