Skip to main content
. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Mol Genet Metab. 2012 Nov 28;108(1):56–64. doi: 10.1016/j.ymgme.2012.11.010

Fig 3.

Fig 3

Effect of α-syn secondary structure on GCase activity. A, Comparison of GCase activity in the presence of NaTc (black) and POPC/POPS vesicles (gray) upon the addition of α-syn. B, GCase titration curve obtained from mean spectral wavelength (<λ>) of Dns136-α-Syn at pH 5.5 in the presence of 3 mM NaTc. Fit is shown as a line. Inset, Circular dichroism spectra of α-syn in the presence of NaTc (black) and POPC/POPS vesicles (gray). C, A schematic diagram depicting that while α-syn interacts with GCase in the presence of both NaTc and POPC/POPS vesicles, only the α-helical vesicle-bound α-syn inhibits enzyme activity.