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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Mol Genet Metab. 2012 Nov 28;108(1):56–64. doi: 10.1016/j.ymgme.2012.11.010

Fig 4.

Fig 4

Mechanism of inhibition by α-syn. A, GCase (10 nM) reaction velocity as a function of added 4MU-β-glu in the presence of 0 μM (●), 0.15 μM (■), 0.3 μM (▲) and 1.25 μM (▼) α-syn. Fits to Michaelis-Menten equation for mixed inhibition are shown as lines. B, Plot of apparent Vm(app) vs. Km(app) extracted from fits.