Fig. 5.
ALDH1A1 expression existed in PCa tumors with heterogeneous phenotypes and was associated with a poor prognosis for the patients. A. Immunohistochemical study of adjacent sections of a PCa tumor for the expression of ALDH1A1 and AR showed that ALDH1A1+ cells (arrows in left panel) exist in portion of secretory type cancer epithelial cells that had strong AR immunopositivity (arrowheads in right panel). B. ALDH1A1+ cells (arrows in left panel) were present in part of neuroendocrine tumor cells that had positive chromogranin A (arrowheads in right panel). C. Probability of overall survival (left panel) and cancer-specific survival (right panel) by levels of ALDH1A1 expression in the 99 PCa patients.