Table 1.

Ligand/Substrate Optimization.^a

entry	1	L	solvent	conv. (%)b	anti:synb	erc
1	1b	L1	DMSO	>95	3:1	>99.5:0.5 (98.5:1.5)d
2	1b	L2	DMF	>95	14:1	99:1
3	1b	L2	DMSO	>95	20:1	>99.5:0.5
4	1b	L3	DMF	>95	22:1	>99.5:0.5
5	1b	L3	DMSO	>95 (93)e	29:1	>99.5:0.5
6	1a	L3	DMSO	>95 (91)e	>30:1	>99.5:0.5
7	1c	L3	DMSO	19	–	–

^aReactions performed on 0.155 mmol scale;

^bDetermined by ³¹P NMR analysis of the crude reaction mixture;

^cDetermined by chiral HPLC analysis;

^dSyn isomer;

^eIsolated yield.