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Pelvic appendage skeletal preparations from wild-type (A) and Pitx1 null (B) mice and wild-type (C) and Pitx1 null threespine stickleback (D). (A, B) Mice lacking Pitx1 develop small hindlimbs that have lost some hindlimb characteristics (figure reproduced with permission from Duboc & Logan, 2011). (C, D) Threespine stickleback which lack Pitx1 in the pelvic regions do not develop pelvic spines (figure reproduced with permission from Cole et al. 2003).
