Table 2.
Difference in serum bicarbonate (HCO3) in mEq/L by quartiles of estimated net endogenous acid production compared to the lowest quartile in unadjusted and adjusted models
| Quartile | All Time Points (n = 1334 Observations in 462 Individuals) |
Cross-sectional at Year 2 (n = 343) |
||
|---|---|---|---|---|
| HCO3 Difference | P | HCO3 Difference | P | |
| Unadjusted | ||||
| Quartile 1 (12.5 to 56.7 mEq/d)a | Reference | — | Reference | — |
| Quartile 2 (56.7 to 71.1 mEq/d) | −0.64 (−1.10 to −0.19) | 0.01 | −0.18 (−1.19 to 0.84) | 0.73 |
| Quartile 3 (71.3 to 89.0 mEq/d) | −0.97 (−1.51 to −0.43) | 0.001 | −0.71 (−1.73 to 0.30) | 0.17 |
| Quartile 4 (89.1 to 152.1 mEq/d) | −1.35 (−1.92 to −0.78) | <0.001 | −1.69 (−2.70 to −0.67) | 0.001 |
| Continuous per 10 mEq/d | −0.17 (−0.25 to −0.09) | <0.001 | −0.19 (−0.34 to −0.05) | 0.01 |
| Adjustedb | ||||
| Quartile 1 (12.5 to 56.7 mEq/d) | Reference | — | Reference | — |
| Quartile 2 (56.7 to 71.1 mEq/d) | −0.60 (−1.03 to −0.17) | 0.01 | −0.11 (−1.06 to 0.84) | 0.83 |
| Quartile 3 (71.3 to 89.0 mEq/d) | −0.87 (−1.37 to −0.37) | 0.001 | −0.51 (−1.48 to 0.47) | 0.31 |
| Quartile 4 (89.1 to 152.1 mEq/d) | −1.27 (−1.79 to −0.74) | <0.001 | −1.33 (−2.31 to −0.35) | 0.01 |
| Continuous per 10 mEq/d | −0.16 (−0.23 to −0.08) | <0.001 | −0.17 (−0.30 to −0.03) | 0.02 |
a
Ranges refer to quartiles defined in the cross-sectional 2-year study population.
b
Adjusted for age, gender, diabetes, 24-h urinary sodium, estimated glomerular filtration rate, albuminuria, body mass index, smoking, randomized treatment group in trial phase, and current use of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker and diuretics.