Table 3.

Simulated difference in serum bicarbonate (HCO₃) in mEq/L per 10 mEq/d higher net endogenous acid production (NEAP) using errors in variable regression across a range of reliabilities in net endogenous acid production estimation (n = 343)

Theoretical Reliability	HCO3 Difference per 10 mEq/d NEAP (95% Confidence Interval)	P
0.90	−0.19 (−0.34 to −0.03)	0.02
0.80	−0.21 (−0.38 to −0.04)	0.02
0.70	−0.24 (−0.44 to −0.04)	0.02
0.60	−0.29 (−0.53 to −0.05)	0.02

The values were adjusted for age, gender, diabetes, 24-h urinary sodium, estimated glomerular filtration rate, albuminuria, body mass index, smoking, randomized treatment group in trial phase, and current use of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker and diuretics.