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Human, C. elegans, and Drosophila BCL-2 family members. BH motifs are numbered, BH4 (light gray, unnumbered box indicates traditional classification without verified sequence homology), BH3 (black), BH1-BH2 (white), transmembrane (dark gray), arrows (protease cleavage sites). Splice variants (isoforms) are shown as separate or partially overlapped diagrams. Scale bar at the bottom marks increments of 50 amino acids.
