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. Author manuscript; available in PMC: 2014 Jan 10.
Published in final edited form as: J Med Chem. 2012 Dec 19;56(1):320–329. doi: 10.1021/jm3016393

Figure 3.

Figure 3

Figure 3

Figure 3a. Binding of 2 to RTA showing unexpected edge-to-face interaction

Figure 3b. Comparison of inhibitors with Gly-Gly and Gly-Phe pendants. The RTA active site is shown as the thinner bonds and the ligands with thicker bonds. Carbons of 2 are light, while those of the Gly-Gly ligand are dark. Waters are shown as spheres.